Caredio D, Mariutti G, Polzer L, Gatta B, Cerisoli M, Laimeche Y, Miracca G, Droux J, El Amki M, Emmenegger M, Hruska-Plochan M, Wegener S, Polymenidou M, Schmitz M, Zerr I, De Cecco E, Aguzzi A (2026) Gpnmb defines a phagocytic state of microglia linked to cell death in prion disease mouse model. Nat Commun
Condrau J, Gluck C, Wyss MT, Hosli L, Erlebach E, Zanker HS, von Faber-Castell A, Ravotto L, Eberle G, Allu SR, Esipova TV, Troxler T, Bennett JL, Herwerth M, Wegener S, Saab AS, Vinogradov SA, El Amki M, Weber B (2026) Intrinsic endothelial remodeling drives brain capillary repair. Neuron
Deseoe J, de la Rosa E, Haensel M, Herzog L, Luft AR, Sick B, Steffel J, Breitenstein A, Lip GYH, Menze B, Wegener S (2026a) Deep learning enables diagnosis of atrial cardiomyopathy from routine 12-lead electrocardiogram. medRxiv:2026.01.12.26343962
Deseoe J, Hänsel M, Herzog L, Davoudi N, Luft AR, Gebhard C, Menze B, Sick B, Wegener S (2026b) The ratio of left atrial and ventricular volume as new marker of atrial cardiopathy with relevance for stroke risk and cognitive dysfunction. Stroke, In Press June 2026
Droux J, Husson J, Glück C, Preuss H, Del Campo Fonseca A, Bergaglio T, Otto LB, Sparano C, Hösli L, Glandorf L, Palmier B, Solsona ST, Razansky D, Margaill I, Greter M, Ahmed D, Casanova Acebes M, Nishimura N, Schaffer CB, Hidalgo A, Weber B, Wegener S*, El Amki M* (2026) Reprogrammed neutrophils with impaired transit mechanics drive multi-organ capillary stalling after stroke. bioRxiv:2026.02.10.705064
Handelsmann HL, Herzog L, Hoving AJ, Majoie C, Van Zwam W, Van der Lugt A, Wegener S, Investigators MC (2026a) Futile recanalisation in patients with anterior large vessel occlusion stroke randomised to mechanical thrombectomy. J Neurol Sci 482:125772
Inauen C, Barnaure I, Herzog L, Schegg W, Esposito G, Kulcsar Z, Bogli SY, Luft A, Johansson E, Wegener S (2026) Duplex ultrasound in severe carotid stenosis: diagnostic performance for differentiating near-occlusion subtypes from conventional high-grade stenosis. Neuroradiology
Middleham W, Binder NF, Deseo J, Weber R, Zolotko K, Droux J, Yoshihara H, Wyss MT, Luft AR, Weber B, Razansky D, El Amki M, Wegener S (2026) Cardiovascular exercise mitigates reperfusion failure and persistent hypoperfusion in the thrombin model of stroke and thrombolysis. J Cereb Blood Flow Metab:271678X251405677
Yang K, Shi P, Huang H, Musio F, Baazaoui H, Aydin OU, Hilbert A, Hamadache RE, Yalcin C, Zhang M, Falcetta D, de la Rosa E, Shit S, Prabhakar C, Wittmann B, Rokuss MR, Kirchhoff Y, Al-Maskari R, Höher L, Juchler N, Casamitjana A, Cleary J, Schmick A, Baumgartner P, Deseö J, Vandans O, Lee D, Oh K, LaBella D, Mazher M, Niederer SA, Qayyum A, Liu Y, Chen J, Kim W, Asawalertsak N, Kim M, Shin D, Park S-H, Kikuchi S, Zhang Y, Liu J, Cui Y, Qiu Y, Verschuur A, Zhang J, van der Schaaf I, Su R, Tax CMW, Yamagishi Y, Letchumanan N, Hanaoka S, González J, Tiberi R, Lisazo C, Abramova V, Lal-Trehan Estrada UM, Lathulerie AC, Díaz MR, Oliver A, Zhang M, Bai Z, Maier-Hein K, Gu Y, Lladó X, Zuluaga MA, Frey D, Paetzold JC, Hirsch S, Wegener S, Ma Y, Menze B (2026) TopBrain Segmentation Challenge for Whole Brain Vessel Anatomy. In Press NEJM AI June 2026; medRxiv:2026.05.28.26354312
2025
Van Hove, H., Glück, C., Mildenberger, W., Petrova, E., Maheshwari, U., Häne, P., Kreiner, V., Bijnen, M., Mussak, C., Utz, S. G., Droux, J., Ingelfinger, F., Ashworth, C., Stifter, S. A., Roussel, E., Lelios, I., Vermeer, M., Huang, S.-F., Zhou, Q., … Greter, M. (2025).Interleukin-34-dependent perivascular macrophages promote vascular function in the brain. Immunity, 58(5), 1289–1305.e8. https://doi.org/10.1016/j.immuni.2025.04.003
Baazaoui, H., Engelter, S. T., Gensicke, H., Enz, L. S., Psychogios, M., Mutke, M., Michel, P., Strambo, D., Salerno, A., Marquering, H. A., Nederkoorn, P. J., Wali, N., Tanadini-Lang, S., Menze, B., de la Rosa, E., Yang, K., De Marchis, G. M., Dittrich, T. D., Valletta, F., Germann, M., … Wegener, S. (2025).The multicentre acute ischemic stroke imaging and clinical data (MAGIC) repository: Rationale and blueprint. Frontiers in Neuroinformatics, 18, 1508161. https://doi.org/10.3389/fninf.2024.1508161
Baumgartner, P., Zahn, M., Handelsmann, H. L., Geier, K., Petrus, S., Hänsel, M., Mayr, K., Pipping, T., Luft, A. R., Herzog, L., & Wegener, S. (2025).Optic nerve sheath diameter for prediction of intracranial hypertension after ischemic stroke: The ONSITE study. European Stroke Journal. Advance online publication. https://doi.org/10.1177/23969873251379985
Chen, Z., Zhou, Q., Droux, J., Liu, Y. H., Glück, C., Gezginer, I., Wyss, M., Yoshihara, H. A. I., Kindler, D. R., Weber, B., Wegener, S., El Amki, M., & Razansky, D. (2025).Transcranial cortex-wide imaging of murine ischemic perfusion with large-field multifocal illumination microscopy. Stroke, 56(1), 170–182. https://doi.org/10.1161/STROKEAHA.124.047996
de la Rosa, E., Reyes, M., Liew, S. L., Hutton, A., Wiest, R., Kaesmacher, J., … Wiestler, B. (2025).DeepISLES: A clinically validated ischemic stroke segmentation model from the ISLES’22 challenge. Nature Communications, 16(1), 7357. https://doi.org/10.1038/s41467-025-47357-0
Hansel, M., Mauch, E., Micheloud, C., Luft, A. R., Nedeltchev, K., Arnold, M., & Wegener, S. (2025).Current trends in stroke events, mortality, and case fatality in Switzerland: An epidemiologic update. International Journal of Epidemiology, 54(4), dyaf087. https://doi.org/10.1093/ije/dyaf087
Thieren, L., Zanker, H. S., Droux, J., Dalvi, U., Wyss, M. T., Waag, R., … Saab, A. S. (2025).Astrocytic GLUT1 deletion in adult mice enhances glucose metabolism and resilience to stroke. Nature Communications, 16(1), 4190. https://doi.org/10.1038/s41467-025-44190-9
Westphal, L. P., Rüttener, L., Gasser, T., Luft, A. R., Held, U., & Wegener, S. (2025).Sex differences in the pre- and in-hospital setting of patients with stroke are driven by higher age and stroke severity. Stroke, 56(2), 256–264. https://doi.org/10.1161/STROKEAHA.124.048303
2024
Binder, N. F., El Amki, M., Glück, C., Middleham, W., Reuss, A. M., Bertolo, A., … Wegener, S. (2024).Leptomeningeal collaterals regulate reperfusion in ischemic stroke and rescue the brain from futile recanalization. Neuron, 112(9), 1456–1472.e6. https://doi.org/10.1016/j.neuron.2024.01.031
Glück, C., Zhou, Q., Droux, J., Chen, Z., Glandorf, L., Wegener, S., Razansky, D., Weber, B. & El Amki, M. (2024).Pia-FLOW: Deciphering hemodynamic maps of the pial vascular connectome and its response to arterial occlusion. Proceedings of the National Academy of Sciences, 121(28), e2402624121. https://doi.org/10.1073/pnas.2402624121
Kaufmann, J. E., Engelter, S. T., Wegener, S., & TREAT-CAD Trial Investigators. (2024).Toward individual treatment in cervical artery dissection: Subgroup analysis of the TREAT-CAD randomized trial. Annals of Neurology, 95, 886–897.
Mikail, N., Sager, D. F., Gebert, P., Haider, A., Todorov, A., Bengs, S., … Gebhard, C. (2024).Imaging of the brain–heart axis: Prognostic value in a European setting. European Heart Journal, 45, 1613–1630.
Rohner, M. H., Gebhard, C., Luft, A. R., Hänsel, M., & Wegener, S. (2024).Cardiac findings following cerebrovascular disease. Journal of the American Heart Association, 13(17), e034131. https://doi.org/10.1161/JAHA.124.034131
Wegener, S., Baron, J. C., Derdeyn, C. P., Fierstra, J., Fromm, A., Klijn, C. J. M., van Niftrik, C. H. B., & Schaafsma, J. D. (2024).Hemodynamic stroke: Emerging concepts, risk estimation, and treatment. Stroke, 55(7), 1940–1950. https://doi.org/10.1161/STROKEAHA.123.044386
Zhou, Q., Glück, C., Tang, L., Glandorf, L., Droux, J., El Amki, M., Wegener, S., Weber, B., Razansky, D., & Chen, Z. (2024).Cortex-wide transcranial localization microscopy with fluorescently labeled red blood cells. Nature Communications, 15, 3526. https://doi.org/10.1038/s41467-024-47941-4
2023
Baumgartner, P., Kook, L., Altersberger, V. L., Gensicke, H., Ardila-Jurado, E., Kägi, G., … TRISP Collaborators. (2023). Safety and effectiveness of IV thrombolysis in retinal artery occlusion: A multicenter retrospective cohort study. European Stroke Journal, 8(4), 966–973. https://doi.org/10.1177/23969873231185895
Dean-Ben, X. L., Robin, J., Nozdriukhin, D., Ni, R., Zhao, J., Glück, C., … Razansky, D. (2023). Deep optoacoustic localization microangiography of ischemic stroke in mice. Nature Communications, 14, 3584. https://doi.org/10.1038/s41467-023-39249-9
Del Campo Fonseca, A., Glück, C., Droux, J., Ferry, Y., Frei, C., Wegener, S., Weber, B., El Amki, M., & Ahmed, D. (2023). Ultrasound trapping and navigation of microrobots in the mouse brain vasculature. Nature Communications, 14, 5889. https://doi.org/10.1038/s41467-023-41487-1
Dubs, L., Charitatos, V., Buoso, S., Wegener, S., Winklhofer, S., Alkadhi, H., & Kurtcuoglu, V. (2023). Assessment of extracranial carotid artery disease using digital twins: A pilot study. NeuroImage: Clinical, 38, 103435. https://doi.org/10.1016/j.nicl.2023.103435
Epp, R., Glück, C., Binder, N. F., El Amki, M., Weber, B., Wegener, S., Jenny, P., & Schmid, F. (2023). The role of leptomeningeal collaterals in redistributing blood flow during stroke. PLoS Computational Biology, 19, e1011496. https://doi.org/10.1371/journal.pcbi.1011496
Herzog, L., Kook, L., Götschi, A., Petermann, K., Hänsel, M., Hamann, J., Dürr, O., Wegener, S., & Sick, B. (2023). Deep transformation models for functional outcome prediction after acute ischemic stroke. Biometrical Journal, 65(6), e2100379. https://doi.org/10.1002/bimj.202100379
Herzog, L., Kook, L., Hamann, J., Globas, C., Heldner, M. R., Seiffge, D., … Wegener, S. (2023). Deep learning versus neurologists: Functional outcome prediction in LVO stroke patients undergoing mechanical thrombectomy. Stroke, 54(7), 1761–1769. https://doi.org/10.1161/STROKEAHA.123.042496
Mujanovic, A., Ng, F., Meinel, T. R., Dobrocky, T., Piechowiak, E. I., Kurmann, C. C., … Kaesmacher, J. (2023). No-reflow phenomenon in stroke patients: A systematic literature review and meta-analysis of clinical data. International Journal of Stroke. Advance online publication. https://doi.org/10.1177/17474930231180434
Seystahl, K., Martinez-Majander, N., Salerno, A., Beyeler, M., Erdur, H., Marto, J. P., … Wegener, S. (2023). IV thrombolysis with or without endovascular treatment for suspected ischemic stroke in patients with intracranial tumors. Neurology, 101(12), e1241–e1255. https://doi.org/10.1212/WNL.0000000000207624
Widmer, R. E., Bink, A., Hamann, J., Herzog, L., El Amki, M., Sarikaya, H., Kulcsar, Z., Luft, A. R., & Wegener, S. (2023). Resolving the smoking paradox: No evidence for smoking-induced preconditioning in large vessel occlusion stroke. European Neurology, 86(5), 325–333. https://doi.org/10.1159/000533436
2022
Binder, N. F., Glück, C., Middleham, W., Alasoadura, M., Pranculeviciute, N., Wyss, M. T., Chuquet, J., Weber, B., Wegener, S., & El Amki, M. (2022). Vascular response to spreading depolarization predicts stroke outcome. Stroke, 53(4), 1386–1395. https://doi.org/10.1161/STROKEAHA.121.038085
Hänsel, M., Steigmiller, K., Luft, A. R., Gebhard, C., Held, U., & Wegener, S. (2022). Neurovascular disease in Switzerland: 10-year trends show non-traditional risk factors on the rise and higher exposure in women. European Journal of Neurology, 29(9), 2851–2860. https://doi.org/10.1111/ene.15434
Zhou, Q., Chen, Z., Liu, Y. H., El Amki, M., Glück, C., Droux, J., Reiss, M., Weber, B., Wegener, S., & Razansky, D. (2022). Three-dimensional wide-field fluorescence microscopy for transcranial mapping of cortical microcirculation. Nature Communications, 13, 7969. https://doi.org/10.1038/s41467-022-35730-9
2021
Hamann, J., Herzog, L., Wehrli, C., Dobrocky, T., Bink, A., Piccirelli, M., … Wegener, S. (2021). Machine-learning-based outcome prediction in stroke patients with middle cerebral artery M1 occlusions and early thrombectomy. European Journal of Neurology, 28(4), 1234–1243. https://doi.org/10.1111/ene.14651
van Niftrik, C. H. B., Sebök, M., Wegener, S., Esposito, G., Halter, M., Hiller, A., Stippich, C., Luft, A. R., Regli, L., & Fierstra, J. (2021). Increased ipsilateral posterior cerebral artery P2-segment flow velocity predicts hemodynamic impairment. Stroke, 52, 1469–1472. https://doi.org/10.1161/STROKEAHA.120.031561
von Bieberstein, L., van Niftrik, C. H. B., Sebök, M., El Amki, M., Piccirelli, M., Stippich, C., Regli, L., Luft, A. R., Fierstra, J., & Wegener, S. (2021). Crossed cerebellar diaschisis indicates hemodynamic compromise in ischemic stroke patients. Translational Stroke Research, 12(1), 39–48. https://doi.org/10.1007/s12975-020-00821-0
Westphal, L. P., Lohaus, N., Winklhofer, S., Manzolini, C., Held, U., Steigmiller, K., … Wegener, S. (2021). Circle of Willis variants and their association with outcome in patients with middle cerebral artery M1 occlusion stroke. European Journal of Neurology, 28(11), 3682–3691. https://doi.org/10.1111/ene.15013
2020
El Amki, M., Glück, C., Binder, N. F., Middleham, W., Wyss, M. T., Weiss, T., Meister, H., Luft, A. R., Weller, M., Weber, B., & Wegener, S. (2020). Neutrophils obstructing brain capillaries are a major cause of no-reflow in ischemic stroke. Cell Reports, 33(2), 108260. https://doi.org/10.1016/j.celrep.2020.108260
Herzog, L., Murina, E., Dürr, O., Wegener, S., & Sick, B. (2020). Integrating uncertainty in deep neural networks for MRI-based stroke analysis. Medical Image Analysis, 65, 101790. https://doi.org/10.1016/j.media.2020.101790
Westphal, L. P., Widmer, R., Held, U., Steigmiller, K., Hametner, C., Ringleb, P., … TRISP Study Group. (2020). Association of prestroke metformin use, stroke severity, and thrombolysis outcome. Neurology, 95(4), e362–e373. https://doi.org/10.1212/WNL.0000000000009951